T Cell co-inhibitory molecules in sepsis induced immunosuppression: from bench to bedside

Department of Critical Care Medicine， Zhongda Hospital， School of Medicine， Southeast University

目的: Sepsis induced immunosuppression, especially adaptive immunosuppression, is an important cause of opportunistic infection in the late stage of sepsis, which induce a significant morbidity and mortality. T cells play a crucial role in adaptive immune function, is consider to be most important in sepsis induced adaptive immunosuppression. The balance of the co-signalling molecules controls the immunological response, which indicates that the co-inhibitory receptors expressed on the T cells are the potential targets for sepsis immunotherapy.